Return to compound report

Overview

Curve fitting method

Dose response curves fit for BRD-K05804044.Robust 4-parameter dose-response curves (DRCs) are fit for each cell line using the viability metrics (see the Data Processing section). The four parameters are upper limit, lower limit, slope, and EC50. The equation for the curve is defined:

\[f(x) = b + \frac{a-b}{1+e^{s\log{\frac{x}{EC50}}}}\]

These data, in addition to the area under the dose-response curves (AUC) and the concentration at which the curve reaches 0.5 viability (IC50), are presented in the table below the plots. Some cell lines may be missing due to insensitivity and/or inability to fit a standard curve to the data (see a standard PRISM report for more information on curve fitting techniques).

The table and plots are interactive. To highlight a cell line either search it using the search box or select it in the table.

Plots